Die Magus, Die!

The elite corps of House Deneith whose abilities are focused to the
destruction of spell casters are the deadly Deneith Mage Slayers. Highly
resistant to magic, able to take the damage a spell caster can dish out,
and with the ability to protect themselves from arcane spells, the Mage
Slayer is a deadly enemy for any caster. Learn how to make one with
Darkgolem's new build, the Mage Slayer!

"In combat, the Deneith Mage slayer should single out spell casters for
death, moving quickly to them (using sprint boost) and then beating
their opponent to pulp."

You can examine the build at Ten Ton Hammer's DDO Site.